Ranya Ghamri

and 2 more

Objective: We aimed to determine the correlation of cardiovascular risk parameters with serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI). Methods: This cross-sectional study was conducted among patients admitted to the intensive care unit (ICCU) King Abdulaziz University Hospital, Jeddah, from March 2019-February, 2020. Blood samples and other data were collected from 100 adult AMI patients admitted to the ICCU (age, 40–60 years) and from 40 age- and BMI-matched healthy adults. Results: The comparison of median and interquartile range of the IL-6 and hs-CRP levels showed that the median values in the MI group were significantly higher than in the healthy control (p < 0.001). Levels of FPG, HbA1c, TG, LDLc were significantly higher, while HDLc was significantly lower in MI patients than control subjects. In the MI group, hs-CRP showed a significant correlation with BMI (r=0.531; p<0.001), and waist circumference (r=0.448; p<0.001). With regard to the gender-based comparison, the hs-CRP and IL-6 levels were not significantly different in male and female MI patients (5.90±2.0 vs. 6.80±8.2; p=0.166 and 21.23±8.2 vs. 21.06 ±8.7; p=0.948, respectively). However, IL6 levels were significantly different between males and females in the control groups (6.64±3.0 vs. 9.74±4.7;p=0.017). Conclusion: IL-6 and hs-CRP were significantly higher in MI than the healthy group. No correlation was found with biochemical parameters. Further research is needed to explore the pathways involving these two molecules in the pathogenesis of MI. Keywords: Myocardial infarction, interleukin-6, cardiovascular risk parameters, C-reactive protein, HDL-c