Correlation of cardiovascular risk parameters with serum interleukin-6
and C-reactive protein in patients with myocardial infarction
Abstract
Objective: We aimed to determine the correlation of cardiovascular risk
parameters with serum interleukin-6 (IL-6) and high-sensitivity
C-reactive protein (hs-CRP) in patients with acute myocardial infarction
(AMI). Methods: This cross-sectional study was conducted among patients
admitted to the intensive care unit (ICCU) King Abdulaziz University
Hospital, Jeddah, from March 2019-February, 2020. Blood samples and
other data were collected from 100 adult AMI patients admitted to the
ICCU (age, 40–60 years) and from 40 age- and BMI-matched healthy
adults. Results: The comparison of median and interquartile range of the
IL-6 and hs-CRP levels showed that the median values in the MI group
were significantly higher than in the healthy control (p <
0.001). Levels of FPG, HbA1c, TG, LDLc were significantly higher, while
HDLc was significantly lower in MI patients than control subjects. In
the MI group, hs-CRP showed a significant correlation with BMI (r=0.531;
p<0.001), and waist circumference (r=0.448;
p<0.001). With regard to the gender-based comparison, the
hs-CRP and IL-6 levels were not significantly different in male and
female MI patients (5.90±2.0 vs. 6.80±8.2; p=0.166 and 21.23±8.2 vs.
21.06 ±8.7; p=0.948, respectively). However, IL6 levels were
significantly different between males and females in the control groups
(6.64±3.0 vs. 9.74±4.7;p=0.017). Conclusion: IL-6 and hs-CRP were
significantly higher in MI than the healthy group. No correlation was
found with biochemical parameters. Further research is needed to explore
the pathways involving these two molecules in the pathogenesis of MI.
Keywords: Myocardial infarction, interleukin-6, cardiovascular risk
parameters, C-reactive protein, HDL-c