Objective: To assess the sealing effect of a Magnetic-Sealing Uterine Manipulator (MUM) in isolated uterus. Design: Non - intervention study. Setting: This study was conducted at the First Affiliated Hospital of Xi’an Jiaotong University from November 2019 to April 2021. Population: Patients with early-stage cervical cancer who underwent radical laparotomy hysterectomy. Methods: The MUM closure test (group 2) and the control test (right-angle forceps closure tests, group 1 and 3) were carried out in an isolated uterus. Main outcome measure: DNA ploidy analysis system was used to analyze the exfoliated cells. Statistical analysis was performed using Wilcoxon signed rank test to assess the sealing effect of MUM. Results: We identified 36 patients. None regional node metastasis was found in all cases and only one of their tumors was larger than 4.0 cm. The mean numbers of exfoliated tumor cells in groups 1, 2, and 3 were 1, 1, and 2, respectively. There was no significant difference in the number of exfoliated cells between group 1 and group 3 (p=0.476). We merged the results of group 1 and 3. Furthermore, there was significant difference between right-angle forceps closure tests and MUM closure test (p=0.022). Conclusion: The sealing effect for MUM was better than the right-angle forceps. The MUM can effectively seal the cervical cancer cells in the cup cover and avoid the dissemination of tumor cells.

Background More evidence has shown FDG PET/CT parameters might be associated with survival of patients with locally advanced cervical cancer (LACC) treated with concurrent chemo-radiotherapy (CCRT). Objectives To perform this meta-analysis to investigate the prognostic value of pretreatment FDG PET/CT parameters. Search strategy PubMed and Embase. Selection criteria Studies that met the following criteria were enrolled: patients treated with CCRT for LACC; FDG PET/CT scans performed before or during treatment; and relationship between the parameters of FDG PET/CT and the prognosis of patients were investigated. Data collection and analysis Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate overall survival (OS) or event-free survival (EFS). Main results Higher primary tumor TLG (HR = 1.843, 95% CI = 1.100–3.086, P = 0.02) and MTV (HR = 2.06, 95% CI, 1.21–3.51, P = 0.007) were significantly associated with shorter EFS. Patients with high SUVmax have a shouter OS than those with low SUVmax (HR = 2.582, 95% CI 1.936–3.443, P <0.001). Primary tumor SUVmax (HR = 1.938, 95% CI, 1.203–3.054, P = 0.004) and nodal SUVmax (HR = 3.478, 95% CI = 2.006-6.029, P <0.001) were significantly correlated with EFS with relatively high heterogeneity (I2 = 84%, I2 = 69.4%, respectively). Nodal SUVmax (HR = 2.095, 95% CI = 2.027–2.166, P <0.001) were significantly correlated with OS with relatively high heterogeneity (I2 = 54.1%, P = 0.140). Other parameters had no detected association with survival. Conclusions Pretreatment FDG PET/CT parameters serve as a prognostic predictor.

Objective: To investigate the feasibility and diagnostic accuracy of endometrial biopsy using Li Brush sampler in IUD users. Design: Clinical research Setting: A public teaching hospital in China. Population: IUD users with irregular uterine bleeding and IUD non-users who arranged for dilatation and curettage at the First Affiliated Hospital of Xi’an Jiaotong University, China from January 2018 to January 2020. Methods: This study was conducted in two parts. Part Ⅰ was to assess the impact of Li Brush on the position of IUDs. Transvaginal ultrasound was used to locate IUDs before and after sampling. Part Ⅱ was to explore the diagnostic accuracy of Li Brush in detecting endometrial lesions. Both IUD users and non-users were recruited, and the sampling satisfaction and accuracy of Li Brush were evaluated. Main outcome Measures: The positions of IUDs before and after sampling, cytopathological and histopathological diagnosis, sampling satisfaction rate. Results: Seventeen cases in part Ⅰ confirmed no significant difference in the position of IUDs before and after sampling (p=0.20). 112 IUD users and 139 IUD non-users were recruited in part Ⅱ. The Li Brush achieved 94.64% and 92.09% sampling satisfaction in the IUD group and control group, respectively, and the overall diagnostic accuracy was 88.04% and 93.33% in the two groups. Conclusions: Li Brush used for endometrial biopsy did not affect the position of IUDs and had high sampling satisfaction and accuracy for endometrial diagnoses.