Objective The aim of this study was to evaluate the effect of preoperative anxiety on depth of anesthesia and IVF success. Design Population-based cohort study. Setting Trakya University Population or Sample 131 patients between 25 and 43 years of age who were scheduled for oocyte retrieval under sedation. Methods The patients were divided according to Beck Anxiety Inventory (BAI): patients without anxiety were enrolled in the low-anxious group (Group L) and patients with anxiety were included in the high-anxious patient group (Group H). Hemodynamic stability, fertilization rate and good quality embryo (GQE) rate were recorded. Total propofol and fentanyl consumption was assessed intraoperatively. Main Outcome Measures Depth of anesthesia and IVF success Results The fertilization rate and GQE rate were not significant between the group L and group H. Total propofol consumption was significantly higher in group H than in groups L. The Heart rate (HR) at preoperative and postoperatively and systolic arterial pressure (SAP) at preoperatve and diastolic arterial pressure (DAP) at postoperative were significantly increased in groups H than in group L. The time for Modified Aldrete score (MAS) to reach 9 was significantly increased in group H than in group L. The effect of variables that were found significantly in the univariate analysis (Propofol, HRpreop, HRpostop, SAPpreop, DAPpostop, and MAS reach of time 9) on BAI score. Conclusions Total propofol consumption was higher in the high level of anxiety patients, but it was not have negative effect on IVF success. Funding Project by the Trakya University