Vincent Camus - Authorea

IntroductionCarotidodynia or Fay’ syndrome is characterized as neck pain near the carotid bifurcation (1). Three main differential diagnoses can be responsible for carotidodynia : carotid dissection, cervical osteoarthritis and large vessel vasculitis ie Takayasu disease, giant cell arteritis. The definition of carotidodynia has evolved in the past century: initially classified in the International Classification of Headache Disorders (ICHD) in 1988 and then declassified due to unspecific clinical signs in 2004 (2).Over the last decade, reports of perivascular inflammation of the carotid artery have been described in patients with neck pain called TIPIC syndrome: Transient Perivascular Inflammation of the Carotid Artery. The diagnostic criteria for this rare vascular disorder were established by Lecler et al. in 2017 : acute neck pain directly around the level of the carotid bifurcation, eccentric pericarotidian infiltration on imaging, exclusion of another vascular or nonvascular diagnosis with imaging and improvement within 14 days either spontaneously or with anti-inflammatory treatment (1). A recent multicenter retrospective study of 72 patients with TIPIC syndrome confirmed the benign nature of this disorder and that recurrence may occur in up to 20% of cases (Micieli E et al. Transient perivascular inflammation of the carotid artery (TIPIC) syndrome; Vasa 2022). However, TIPIC pathophysiology and triggers remain poorly understood.We report herein the case of a myelodysplastic syndrome (MDS) patient with granulocyte colony stimulating factor (GCSF) induced TIPIC syndrome.