Hi Reddit, We’re Paul Oberstein, MD and Manji Gulam, MD, PhD, from the Medical Oncology department at Columbia University Medical Center. We are so happy to be here and answer your questions! We work as part of a multidisciplinary center, the Pancreas Center at Columbia University, where we specialize in seeing patients with pancreatic cancer and other gastrointestinal malignancies. Dr. Oberstein: Assistant Professor of Medicine within the Division of Medical Oncology at Columbia University Medical Center. My research focuses on developing novel clinical trials for patients with pancreatic cancer. Research trials emphasize novel agents and translation of promising concepts from the laboratory to the clinic. In particular, I am focused on developing collaborations to expand options for treatment as well as supportive care for patients with advanced cancer. I am the Principal Investigator for over 10 active trials including both therapeutic and supportive care studies, and am conducting research studying the interplay between tumor associated stroma and epithelial cells utilizing mouse models of pancreatic cancer in the Herbert Irving Comprehensive Cancer Center. Pancreatic cancer: why is it so hard to treat? Dr. Manji: Assistant Professor of Medicine within the Division of Medical Oncology at the Columbia University Medical Center. I conduct translational research with the overall goal to develop new treatments for cancer. My focus is on gastrointestinal malignancies, particularly pancreas adenocarcinoma, on which I am conducting preclinical combination immunotherapy studies on genetically engineered mice with pancreas cancer in the laboratory at the Herbert Irving Comprehensive Cancer Center. I am currently the principal investigator of multiple novel combination studies that include immunotherapy in pancreas, esophageal, gastric, and liver cancers, and currently developing other unique strategies to tackle these difficult to treat diseases. I am the recipient of the Young Investigator Award for his preclinical studies in Pancreas Cancer by the American Society of Clinical Oncology. Immune Targeting in Gastrointestinal Malignancies: Finding the Right Combination for the Right Site Dr Oberstein signing as: PO Dr Gulam signing as: MG Edit: Hi Reddit! We’re here, let’s get to it. Proof Edit 2: Thanks for all your great questions, Reddit. We’re signing off for now, but we’ll be checking in tonight and tom morning so keep the questions coming.