Ramesh Araganji

and 5 more

Objective: To determine the impact of low dose aspirin (81mg) on markers of maternal inflammation and placental function. Setting: Rural Southern India Population: Nulliparous women with a singleton pregnancy dated by ultrasound who were enrolled in the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) Trial. Methods: We performed a case control study of women who delivered prematurely compared to term controls in women enrolled in the ASPIRIN trial. Women were prospectively enrolled in an ancillary observational trial wherein maternal serum was collected and measured between 10 to 13 weeks and 17 to 21 weeks of gestation after initiation of aspirin or an identical placebo. Our primary outcome was the impact of aspirin on markers of placental function and maternal inflammation. Results: From 2016-18 with a total of 666 n women enrolled in this ancillary trial of whom 269 were selected for analyte analysis. Women who received low dose aspirin (LDA) had lower levels of Alpha Feto-Protein (AFP) at 10 to 13 weeks than women who received placebo (Placebo) (LDA 18.3 ng/mL vs 21.4 ng/mL -P 0.001). AFP was similar between the two groups at 17 to 21 weeks. No other differences were seen in in C-Reactive protein or Anti-Mullerian Hormone. Conclusion: Low dose aspirin administration lowers AFP early in pregnancy and may be a marker of Aspirin efficacy. Keywords: maternal serum alpha-fetoprotein (MSAFP), preterm birth, aspirin Tweetable Abstract: Aspirin decreases AFP in the first trimester; a marker associated with poor birth outcomes.

Geetanjali Katageri

and 14 more

Objective: To understand the extent to which adolescent awareness of and attitudes about anaemia and anaemia prevention can be changed by nutrition messages received at school. Design: Mixed-methods pre–post intervention study Setting: Three Government schools in Bagalkot, Belagavi and Raichur districts of Karnataka, India Population or Sample: Students of grade six and seven and teachers involved in implementing the intervention. Methods: An education intervention was co-developed by school teachers and nutrition experts using locally adapted resource materials that consisted of lectures, role play and practical demonstrations. Seven half-hour educational sessions were delivered by school teachers over seven weeks to 455 students. Pre- and post-intervention tests measured changes in adolescents’ knowledge about anaemia. In-depth interviews with teachers and focus groups with students explored reactions to the intervention. Main outcome measures: Knowledge score related to anaemia Results: The percentage of children with correct scores increased by 7.3 - 49.0 percentage points for the tested questions after implementation of the intervention. The mean knowledge score increased by 3.67±0.17(p<0.01). During interviews, teachers and students highlighted high acceptance of the intervention and materials, an increase in awareness, a positive attitude towards changing behaviour around diet, an increase in the demand for iron folic acid supplements and improved sharing of messages learned with peers and families. Challenges expressed included need for further training, time limitations and hesitancy in teaching about menstruation and pregnancy. Conclusions: Educational interventions carried out for adolescents by teachers in schools are effective in improving awareness and attitude related to anaemia.