Background and purpose Obesity may be more likely to lead to asthma, that is, obesity asthma. Children are the age stage of high incidence of asthma. Obesity asthma may be more refractory in children with asthma, and is more likely to produce glucocorticoid resistance, which greatly leads to the risk of severe disease in children with asthma. However, approaches to combating Obesity Asthma/Childhood Asthma complications are limited by conditions. Existing evidence shows that chrysophanol has antibacterial and anti-inflammatory, fat reduction, anticough, promoting gastrointestinal functional homeostasis and immune regulation. Experimental methods Through systematic pharmacological and bioinformatics analysis, we evaluated the physical and chemical properties and biological activities of chrysophanol, and further analyzed its binding activities, targets, biological functions and mechanisms. Key results It was found that chrysophanol can play the ideal physical and chemical properties and biological activities. The PPI network screened 144 common targets of drugs and diseases, and 15 hub targets were obtained. Then, the top 10 hub targets were identified, namely EGFR, HSP90AA1, ESR1, HIF1A, STAT3, SRC, PTGS2, MTOR, MMP9, PIK3CA, and verified in the protein-ligand blind docking. Enrichment analysis showed that chrysophanol may be involved in inflammation regulation, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Neutrophil extracellular trap formation，and so on. Conclusions and implications Our fingdings indicate that chrysophanol can reduce airway inflammation and remodeling through multi-pathway and multi-target, and provide evidence for the application of chrysophanol in Obesity Asthma/Childhood Asthma comorbidities. The predicted results will be strictly verified by experiments.

Abstract Objectives: This study aimed to identify the related risk factors and potential predictors of SARS-CoV-2 RNA negative conversion by describing the dynamics of viral shedding in infected children admitted to two hospitals from Shanghai during Omicron variant outbreak. Methods: This retrospective cohort included laboratory-confirmed cases of SARS-CoV-2 infection from Shanghai between March 28 and May 31, 2022. Clinical characteristics, personal vaccination, household vaccination rates were collected through electronic health records and telephone interviews. Results: The total of 603 pediatric cases confirmed with COVID-19 was included in this study. Both Univariate and multivariate analysis were performed to filter independent factors for the duration to viral RNA negative conversion. Data on cases re-detected SARS-CoV-2 after showing negative results on RT-PCR test (intermittent negative status) were also analyzed. The median duration of virus shedding was 12(Interquartile Qange,IQR: 10-14) days. The severity of clinical outcome, personal vaccination-2doses, household vaccination rates, abnormal defecation were factors indecently affecting negative conversion of SARS-CoV-2 RNA, suggesting that patient who had abnormal defecation or with more severe condition would delay virological clearance, while patient accepted 2 doses vaccination or with higher household vaccination rates would accelerate virological clearance. Loss of appetite (Odds Ratio (OR) :5.343; 95%CI: 3.307-8.632) and abnormal defecation (OR:2.840; 95%CI: 1.736-4.645) were significantly associated with intermittent negative status. Conclusion: These findings could provide clues for early identification of pediatric patients with prolonged viral shedding, enriching the evidence for development of prevention and control strategies especially the vaccination policies for children and adolescents.