The pterygopalatine fossa, located on both sides of the skull, is a neurovascular crossroad between the middle cranial fossa, the orbit, the nasopharynx, the nasal and oral cavities, and the infratemporal fossa. It is considered a strategically complex region given its small size and the numerous structures that pass through it. This review aims to describe its skeletal framework, content, and communications with other regions.