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Carboplatin-induced Renal Salt Wasting Syndrome in Paediatric Patients with Intracranial Germ Cell Tumours and Concomitant Diabetes Insipidus
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  • Tania Wan,
  • Joanna Tung,
  • Samantha Lee,
  • Alison LT Ma,
  • Anthony Pak Yin Liu,
  • Dennis Ku,
  • Ping-wa Yau,
  • Matthew Shing
Tania Wan
Queen Mary Hospital

Corresponding Author:[email protected]

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Joanna Tung
Hong Kong Children's Hospital
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Samantha Lee
Hong Kong Children's Hospital
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Alison LT Ma
Princess Margaret Hospital
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Anthony Pak Yin Liu
The University of Hong Kong
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Dennis Ku
Hospital for Sick Children
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Ping-wa Yau
Hong Kong Children's Hospital
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Matthew Shing
Hong Kong Children's Hospital
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Abstract

We report the first case series of 14 children with intracranial germ cell tumour (iGCT) and concomitant central diabetes insipidus (DI), who developed hyponatremia secondary to renal salt wasting syndrome (RSWS) following the administration of carboplatin. Clinicians prescribing platinum-based chemotherapy for this group of patients should be alert to the risk of RSWS. Regular monitoring should be performed as hyponatraemia can be asymptomatic until it is severe.
20 Dec 2021Submitted to Pediatric Blood & Cancer
20 Dec 2021Submission Checks Completed
20 Dec 2021Assigned to Editor
21 Dec 2021Reviewer(s) Assigned
10 Jan 2022Review(s) Completed, Editorial Evaluation Pending
10 Jan 2022Editorial Decision: Revise Minor
19 Jan 2022Submission Checks Completed
19 Jan 2022Assigned to Editor
19 Jan 20221st Revision Received
19 Jan 2022Review(s) Completed, Editorial Evaluation Pending
19 Jan 2022Editorial Decision: Accept