Determinar las condiciones perinatales relacionadas con macrosomía fetal, en nuestra población.MÉTODOS:Estudio transversal de los registros del programa publicado por El Centro Latinoamericano de Perinatología, Salud de la Mujer y Reproductiva, archivados en el Hospital Gineco-Obstétrico Isidro Ayora, desde enero del 2008 hasta diciembre del 2016. Para las variables numéricas se aplicó la prueba t. Las variables cualitativas se analizaron con la prueba Chi cuadrado. Para el análisis multivariado se utilizó modelos de regresión. En los resultados se incluye el Odds Ratio crudo y ajustado con el intervalo de confianza al 95%. Los datos fueron analizados con el paquete estadístico R versión. 3.3.1 para Mac.RESULTADOS:Se encontró 1171(5.2%) neonatos macrosómicos. Las variables asociadas a macrosomía fueron diabetes, edad gestacional, edad materna, gestas previas, estado civil, sexo masculino, nacimiento vía cesárea, además existe asociación negativa con embarazo múltiple.CONCLUSIONES:La macrosomía neonatal está relacionada con trastornos metabólicos en la madre, la mayor edad gestacional y materna, acompañamiento de la pareja durante el embarazo, la multiparidad, el producto masculino. El resto de los factores sociales, étnicos, las enfermedades crónicas y los trastornos propios del embarazo no mostraron asociación con macrosomía fetal.

Introduction: Since the first COVID-19 cases were reported, the disease's clinical and epidemiological characteristics have continuously been studied, although they have not been yet defined. Objective: To estimate the epidemiological profile of pediatric patients with COVID-19, as well as their clinical, laboratory and radiological characteristics. Materials and methods: A living systemic review was conducted in the PubMed, Scopus and SciELO databases. Observational studies describing clinical, radiological, and laboratory characteristics of pediatric patients with COVID-considered for the search; there were no language restrictions. Government, epidemiological, and pre-print papers were also considered. Meta-analyses of single proportion (frequentist approach) and two proportions (Bayesian method) were carried out. The study registration and protocol are available at https://osf.io/y43wm and https://osf.io/r8ktv, respectively. Results: 13 studies, with a total of 9 152 patients, were retrieved. The Bayesian meta-analysis reported that males are more affected by the disease: OR 1.24 (HDI95%: 1.09-1.4). The proportion results calculated by means of the frequentist meta-analysis are: 52% cough (95%CI: 50-55), 0% death (95%CI: 0-0.1), 16% high aspartate transaminase levels (95%CI: 13-19), and 60% lung changes observed in chest X-ray (95%CI: 57-64). Conclusions: Based on the current data, it is not possible to describe accurately the clinical and epidemiological characteristics of COVID-19 in the pediatric population. However, evidence suggests that males are more affected by the disease and that lung alterations in imaging studies are more frequent than clinical signs such as cough and fever. Laboratory test results are not conclusive and show that different organs and systems of the human body may be affected by SARS-CoV-2. The results reported here must be compared to prospective controlled studies conducted in larger samples and a more rigorous design.