Long noncoding RNAs (lncRNAs) play an important role in the progression and pathogenesis of many diseases, and have been proved to regulate transcription by transcription factors (TFs). Currently, the pathogenesis of chronic periodontitis (CP) about the interaction between lncRNAs and TFs is little known. So, we explore this interaction through bioinformatics. A dataset from the Gene Expression Omnibus was screened, which contained lncRNA and mRNA Expression profiles of gingival samples from periodontal healthy subjects and CP patients. We identified differentially expressed (DE) lncRNAs and DEmRNAs, and conducted gene Ontology (GO) and Kyoto Gene Genome Encyclopedia (KEGG) pathway enrichment analyses to explore the potential functional and biological pathways of related differentially expressed genes (DEGs). After analyzing the trans-regulation of lncRNAs, we selected 3 lncRNA–TF pairs and examined them by quantitative real-time polymerase chain reaction (qPCR). A total of 13 upregulated lncRNAs and 1 downregulated lncRNA, MIR210HG, were screened from CP patients. Trans analysis showed that the downregulation of lncRNA-MIR210HG corresponded to the upregulation of TFs (IRF4, POU2AF1 and XBP1), which were enriched in positive regulation of cytokine production in GO. Notably, the qPCR results validated the expression of lncRNA-MIR210HG and 3 TFs, further supporting the trans analysis results. LncRNA-MIR210HG and TFs (IRF4, POU2AF1 and XBP1) are significantly involved in the regulatory mechanisms in the pathogenesis of CP. This lncRNA may become a potential biomarker for the diagnosis of CP, providing new clues to explore the regulatory mechanism of lncRNA in the pathogenesis of CP.

A history of recurrent benign mucous membrane pemphigoid episodes had plagued patients. Major treatments include immunosuppressant or systemic glucocorticoid drugs, but all of them have side effects. Therefore, we tried to find a way to minimize side effects by using traditional Chinese medicine, and speeding up the healing process.