GAMZE AVCIOĞLU

and 2 more

Yavuz Otal

and 2 more

Objective: In the present study, the importance of albumin level in severe pneumonia due to covid 19 was investigated. Design: This was a retrospective study. Setting:Emergency Department of Ankara City Hospital, between 1 september 2020 and 1 february May 2021. Subjects: Effective triage and early detection are very important for the control and treatment of coronavirus disease 2019. For this purpose the relation between hypoalbuminemia and other acute phase reactants was compared in severe pneumonia due to Covid-19. Main outcome measures: The data of 122 patients diagnosed with pneumonia due to Covid 19 and 60 healthy control group were retrospectively analyzed in statistical terms in computer medium. The cases were divided into 3 groups as Healthy Control Group, Intubated Group, and Non-Intubated Group. The lung tomography of patients diagnosed with Covid 19 pneumonia was examined one-by-one. The RT-PCR (Real-Time Polymerized Chance Reaction) test results were recorded from the system. The albumin, WBC (White Blood Cell), N/L (Neutrophil/Lymphocyte Ratio), CRP (C-Reactive Protein) levels, who are acute phase reactant levels, of the patients were compared with the Control Group. Also, the two groups who were intubated and not intubated were also compared. Results: When all the data were examined, it was found that the albumin levels were lower at statistically significant levels in all 3 study groups (p<0.01). The other acute phase reactants, N/L ratio and CRP levels were significantly higher (p<0.05). Hypoalbuminemia was found to be significantly lower as a result of the comparisons of the two groups that were intubated and not intubated (p=0.02), and no differences were detected in terms of other parameters (p>0.05). Conclusion: Serum albumin levels may be lower in severe Covid 19 pneumonia. Hypoalbuminemia can be a biomarker indicating the severity of the disease as an acute phase reactant.

Fadime Gullu Haydar

and 7 more

ABSTRACT Background:Metabolic changes seen after obstructive jaundice increase the load of oxidative stress.The thiol-disulphide homeostasis (TDB) has a vital importance as oxidatice stress biomarker. Aim: The aim of present study is to investigate the dynamic thiol-disulphide homeostasis in patients diagnosed with obstructive jaundice and to compare the dynamic thiol-disulphide homeostasis with ischemia modified albumin. Study design: A total of 146 participants who were admitted to emergency department and who consisted of 69 patients and 77 healthy volunteers, were included in the study. Detailed blood samples were obtained from the patients at the time of admission. Methods: Thiol / disulphide levels were examined using a novel method developed by Erel and Neselioglu on the patients diagnosed with obstructive jaundice during the admission. Data were evaluated in computer system. Results: The levels of total thiol (p =0.025) and native thiol (p =0.023) were statistically significantly lower in the patient with obstructive jaundice than in the control group. It was observed that there was a significant negative correlation between the native thiol levels and the ALP (r =-0.262, p<0.01), urea (r =-0.313, p<0.01), total bilirubin (r =-0.388, p<0.01), direct bilirubin (r =-0.351, p<0.01) levels. At the same time, the level of disulphide (p = 0.235) was lower in the patient group than in the control group but not statistically significant. It was found that the ischemia modified albumin (IMA) values were lower in the control group than the obstructive jaundice group (p = 0.03). Conclusion: Total thiol, native thiol and IMA levels decrease in obstructive jaundice pathogenesis.