AUTHOREA
Log in
Sign Up
Browse Preprints
LOG IN
SIGN UP
Essential Maintenance
: All Authorea-powered sites will be offline 9am-10am EDT Tuesday 28 May
and 11pm-1am EDT Tuesday 28-Wednesday 29 May. We apologise for any inconvenience.
Cinzia Lavarino
Public Documents
1
Craniospinal irradiation as a salvage treatment for metastatic relapsed DIPG
Marta Perez-Somarriba
and 6 more
August 23, 2020
Diffuse intrinsic pontine glioma (DIPG) is the most frequent brainstem tumor in children. All therapeutic efforts are palliative, being focal irradiation the only therapy capable of reducing temporarily tumor volume. The vast majority of patients succumb to their disease during the first 2 years after diagnosis usually due to local progression. At first relapse, focal re-irradiation has shown to provide clinical and radiologic benefits. There are no reports of craniospinal irradiation (CSI) as a rescue regimen when progression is local and disseminated. We report a patient treated with CSI at metastatic progression showing clinical and radiological response with good tolerance.