Abstract
We studied the combined effect of gamma radiation (6 Gy, remote period)
and emotional stress on immunological reactivity. At the early period of
emotional stress, all indicators of the immune system, such as cellular,
humoral, and nonspecific phagocytic links of immunity were activated,
indicating the activation of the general adaptive syndrome of the
organism. The suppressive action of gamma radiation on the immune system
was preserved in a remote period, with this suppression being revealed
not only on the T-cellular link, but also on nonspecific phagocytic
links, and the functional-metabolic activity of neutrophils. In the
remote period after the combined effect of sublethal gamma radiation and
emotional stress in the early stage of the adaptation syndrome, there
was a decrease in all cells of the T-system of immunity, in the
functional ability of leukocytes, and in the mononuclear phagocytic
system of the body. The experimental emotional-radiation pathological
process was accompanied by disorders of the functional activity of the
essential adaptive systems of the body. Based on our results, we could
conclude about the dominant role of ionizing radiation in immunological
reactivity.