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Genomic and metabolic insights into Thermoanaerobacterium thermosaccharolyticum GSU5 solvent production
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  • Rocio Díaz Peña,
  • Daniela Alvarez,
  • Diego Egoburo,
  • Jimena Ruiz,
  • Julia Pettinari
Rocio Díaz Peña
University of Buenos Aires
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Daniela Alvarez
University of Buenos Aires
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Diego Egoburo
University of Buenos Aires
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Jimena Ruiz
University of Buenos Aires
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Julia Pettinari
University of Buenos Aires
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Abstract

Thermoanaerobacterium thermosaccharolyticum GSU5 was isolated from animal dung collected in a pasture plain in Buenos Aires, Argentina. This thermophilic and anaerobic microorganism was able to produce butanol and ethanol, but not acetone, using sugars such as xylose, arabinose, glucose, galactose, fructose, sucrose and cellobiose. Key metabolic enzymes leading to solvent production were identified in its genome. A detailed analysis of the solvent and organic acid biosynthetic pathway genes of sequenced strains revealed new insights into the unique metabolic features of this species. The large range of fermentable substrates and the ability to produce both ethanol and butanol without acetone makes this species an interesting candidate for second generation biofuel production.