Potential effects of Resatorvid and Alpha Lipoic Acid on
gentamicin-induced nephrotoxicity in rats
Abstract
Gentamicin (GM) is an aminoglycoside antibiotic with a rapid
bactericidal effect in the treatment of many infections. However, its
use in high concentrations for more than 7 days causes nephrotoxic side
effects. It was aimed to determine the biochemical and molecular
activities of resatorvid and alpha lipoic acid (ALA) on GM induced
nephrotoxicity in rats. In the study, 34 Wistar albino rats were
randomly distributed; Healthy control (n:6), Gentamicin (80 mg/kg, n:7),
Gentamicin+Sham (%10 hydroalcoholic solution, n:7),
Gentamicin+resatorvid (5 mg/kg, n:7), Gentamicin+ALA (100 mg/kg, n:7).
Urinary IL-18, KIM-1 and NGAL levels were statistically decreased by
resatorvid treatment, and KIM-1 levels were statistically decreased by
ALA treatment compared to the gentamicin group. In addition, urine
creatinine was partially decreased by resatorvid and ALA. NRF-2, CAS-3
and NR4A2 expressions were statistically decreased by resatorvid and ALA
treatment. Nevertheless, NF-κB was statistically decreased only with
resatorvid. The nephrotoxicity that limits the use of gentamicin in
infections can reduce by resatorvid in the future. Therefore, it can be
used for a longer and more effective in infections.