5.Conclusion
The use of GM is limited such as in renal failure patients, old people as death may occur due to side effects. Resatorvid and ALA treatments reduced renal dysfunction by antioxidant and anti-inflammatory properties. Resatorvid treatment inhibited the inflammation and renal apoptosis by suppressing the TLR4/NF-kB pathway, so preventing the development of nephrotoxicity. The supporting resatorvid therapy in GM treatment patients may reduce the side effects of GM. Thus, the effective and more widely use of GM antibiotics in the case of rapidly increasing antimicrobial resistance can be achieved.
This experimental result suggests the use of biomarkers such as KIM-1, NGAL, IL-18 instead of urea and creatinine parameters may be more important in the determination of earlier renal damage.
The longer-term and more detailed studies will research a great contribution to reducing the nephrotoxic effects of GM in the future.