5.Conclusion
The use of GM is limited such as in renal failure patients, old people
as death may occur due to side effects. Resatorvid and ALA treatments
reduced renal dysfunction by antioxidant and anti-inflammatory
properties. Resatorvid treatment inhibited the inflammation and renal
apoptosis by suppressing the TLR4/NF-kB pathway, so preventing the
development of nephrotoxicity. The supporting resatorvid therapy in GM
treatment patients may reduce the side effects of GM. Thus, the
effective and more widely use of GM antibiotics in the case of rapidly
increasing antimicrobial resistance can be achieved.
This experimental result suggests the use of biomarkers such as KIM-1,
NGAL, IL-18 instead of urea and creatinine parameters may be more
important in the determination of earlier renal damage.
The longer-term and more detailed studies will research a great
contribution to reducing the nephrotoxic effects of GM in the future.