Strategies for the statins production in microbial cell factory：present
Statins as a lipid-lowering drug can selectively inhibit
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and decrease
cholesterol synthesis effectively. With the improvement of nutritional
conditions, the demand for statins is increasing in global market. Due
to the rapid development of modern biotechnologies, the biosynthesis of
stains by microbial cell factory appears great advantages. It has the
advantages of simple operation and easy separation of products. This
review summarized the strategies on statins production via microbial
cell factory, including both traditional fermentation culture and modern
synthetic biology manufacture. Firstly, the complex fermentation
parameters and process control technology on submerged fermentation
(SmF) and solid-state fermentation (SSF) were introduced in detail.
Especially, the possibility of recoverable agricultural wastes/(Biomass)
as fermentation substrate on solid-state fermentation to produce statins
was emphasized. Besides, metabolic engineering strategies to construct
robust engineering strains and strains evolution were also discussed.
The review highlights the potential and challenge of microbial cell
factory to yield the statins. Thus, it will facilitate the production of
statins in more green production mode.