Developmental endothelial locus-1 in cardiovascular and metabolic
diseases: a promising biomarker and therapeutic target
Cardiovascular and metabolic diseases (CVMDs) are a leading cause of
death worldwide and imposes a huge socioeconomic burden on individuals
and healthcare systems, underscoring the urgent need to develop new drug
therapies. Developmental endothelial locus-1 (DEL-1) is a secreted
multifunctional domain protein that can bind to integrins and play an
important role in the occurrence and development of various diseases.
Recently, DEL-1 has attracted great interest for its pharmacological
role in the treatment and/or management of CVMDs. In this review, we
present the current knowledge on the predictive and therapeutic role of
DEL-1 in a variety of CVMDs, such as atherosclerosis, hypertension,
cardiac remodeling, ischemic heart disease, obesity, and insulin
resistance. Collectively, DEL-1 is a promising biomarker and therapeutic
target for CVMDs.