Coexistence of anti-MDA5 and anti-PL-7 in a patient with
dermatomyositis: a case report
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) and
anti-threonyl-tRNA synthetase (anti-PL-7) are myositis-specific
autoantibodies, associated with rapidly progressive interstitial lung
disease (RP-ILD). A 41-year-old woman presented productive cough,
dyspnea, and muscle pain. Anti-MDA5 and anti-PL-7 were double-positive.
The patient was diagnosed with dermatomyositis-associated ILD, and
responded successfully to glucocorticoids and immunosuppressants.