The world is now experiencing the catastrophe of global pandemic ‘COVID-19’, most serious public health crises in this century. Recently, another virus named “Cat Que Virus” (CQV) seems to be causing its terrible repercussions in the worlds’ largest populous country ‘China’, the origin of SARS-CoV during 2002-2003, and the current pandemic SARS-CoV-2 since December 2019. Recently, the presence of IgG antibody among two persons in the state of Karnataka for CQV was reported in India, the worlds’ second-largest populous country. This means the virus is in circulation in the sub-continent. The presence of the vector mosquitoes (Aedes species, Culex species) and the ambient climatic conditions suitable for vector breeding in the country needs to be taken into account while planning to implement holistic strategies appropriate for control and preventive measures. “One Health approach” is the topmost option covering humans, animals/vectors and the environment to curb the spread/transmission of infectious diseases in general. It is also necessary to study the transmission dynamics and pattern of this emerging virus, its life cycle, the natural reservoir of the virus, the intermediate host and the accidental host with respect South-East Asia, so that necessary remedial action can be planned well before an epidemic. At present, the outbreak of CQV is certainly a warning to the general population around the world. Considering the global imminent health threats posed by CQV, there is an urgent need for active surveillance, monitoring, effective vaccination, and a standard treatment modality of this disease. Given the epidemiological aspect of CQV, control and prevention measures are essential to stop the spread of the virus. At present, there is no information available on CQV; however, this current review article has covered the required data, which will be helpful to control the spread of the CQV.