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Pediatric asthma control during the COVID-19 pandemic: a systematic review and meta-analysis
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  • Ze Yang,
  • Xiang Wang,
  • Xigang Wan,
  • Menglei Wang,
  • Zonghua Qiu,
  • Jiali Chen,
  • Manhao Shi,
  • Shiyi Zhang,
  • Yongliang Xia
Ze Yang
Zhejiang Chinese Medical University
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Xiang Wang
Zhejiang Chinese Medical University
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Xigang Wan
Zhejiang Chinese Medical University
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Menglei Wang
Zhejiang Chinese Medical University
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Zonghua Qiu
Zhejiang Chinese Medical University
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Jiali Chen
Zhejiang Chinese Medical University
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Manhao Shi
Zhejiang Chinese Medical University
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Shiyi Zhang
Zhejiang Chinese Medical University
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Yongliang Xia
Zhejiang Chinese Medical University
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Abstract

Background: During the current ongoing COVID-19 pandemic, studies had reported that patients with asthma would experience increased asthma-associated morbidity because of the respiratory virus SARS-CoV-2 infection, based on experience with other respiratory viral infections. However, some studies suggested that there was no apparent increase in asthma related morbidity in children with asthma, it is even possible that due to reduced exposures due to confinement, such children may have improved outcomes. In order to understand the impact of Covid-19 on asthma control in children, we performed this systematic review and meta-analysis. Methods: We searched PubMed, Embase, and Cochrane Library to find literature from December 2019 to June 2021 related to Covid-19 and children’s asthma control, among which results such as abstracts, comments, letters, reviews and case reports were excluded. The level of asthma control during the COVID-19 pandemic was synthesized and discussed. Results: A total of 20456 subjects were included in 7 studies. Random effect model is used to account for the data. Compared to the same period before the COVID-19 pandemic, asthma exacerbation, asthma admission, emergency room visit reduced a lot. The outcome of use of inhaled corticosteroids and Beta-2 agonists shows no significant difference. Conclusion: Compared to the same period before the COVID-19 pandemic and the measures in response to it, the level of asthma control has been significantly improved. We need to understand the exact factors leading to these improvements and find methods to sustain it.

Peer review status:UNDER REVIEW

19 Jul 2021Submitted to Pediatric Pulmonology
20 Jul 2021Submission Checks Completed
20 Jul 2021Assigned to Editor
22 Jul 2021Reviewer(s) Assigned
11 Aug 2021Review(s) Completed, Editorial Evaluation Pending
21 Aug 2021Editorial Decision: Revise Major
11 Sep 20211st Revision Received
11 Sep 2021Submission Checks Completed
11 Sep 2021Assigned to Editor
11 Sep 2021Reviewer(s) Assigned