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Current Approaches to Management of Bone Sarcoma in Adolescent and Young Adult (AYA) Patients
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  • Katrina Ingley,
  • Alessandra Maleddu,
  • Franel Le Grange,
  • Craig Gerrand,
  • Archie Bleyer,
  • Jeremy Whelan,
  • Sandra Strauss
Katrina Ingley
BC Children's Hospital
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Alessandra Maleddu
University College London Hospitals NHS Foundation Trust
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Franel Le Grange
University College London Hospitals NHS Foundation Trust
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Craig Gerrand
Royal National Orthopaedic Hospital NHS Trust
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Archie Bleyer
Oregon Health & Science University
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Jeremy Whelan
University College London Hospitals NHS Foundation Trust
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Sandra Strauss
University College London Hospitals NHS Foundation Trust
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Abstract

Bone tumors are a group of histologically diverse diseases which occur across all ages. Two of the commonest, osteosarcoma (OS) and Ewing sarcoma (ES), are regarded as characteristic AYA cancers with an incidence peak in AYAs. They are curable for some but associated with unacceptably high rates of treatment failure and morbidity. The introduction of effective new therapeutics for bone sarcomas is slow, and to date, complex biology has been insufficiently characterized to allow more rapid therapeutic exploitation. This review focuses on current standards of care, recent advances that have or may soon change that standard of care and challenges to the expert clinical research community that we suggest must be met.

Peer review status:IN REVISION

13 Jun 2021Submission Checks Completed
13 Jun 2021Assigned to Editor
13 Jun 2021Submitted to Pediatric Blood & Cancer
21 Jun 2021Reviewer(s) Assigned
13 Jul 2021Review(s) Completed, Editorial Evaluation Pending
14 Jul 2021Editorial Decision: Revise Major
14 Sep 2021Assigned to Editor
14 Sep 20211st Revision Received
14 Sep 2021Submission Checks Completed