We searched for clinical trials that investigate acute lymphoblastic leukemia in the pediatric population. PubMed was searched to identify relevant studies. The search strategy is listed in Appendix 1. The search was performed on Tuesday, November 10, 2015.
We searched the PubMed database for clinical
trials associated with treatments for acute lymphoblastic leukemia in pediatric
patients published between 2005 and 2015. The full search strategy is described
in Appendix 1. Over 1000 studies were identified based on the initial search
criteria. These study abstracts (N=1086) were subsequently screened by CCW WDB,
JW, and TEN for inclusion based on the following inclusion exclusion criteria
(INSERT INFORMATION HERE RELATED TO SCREENING CRITERIA including this sentence
-Studies combining original research with meta-analysis were included so as to
not exclude original research.). Disputes over inclusion were resolved via
consensus. Initial screening resulted in 885 articles retained for further review. A random sample of 285 studies was selected
for full text coding. Additional studies were excluded during this process
(e.g., animal studies, genome-wide association studies, adult survivors of
pediatric ALL, and genetic studies). Meta-analyses were excluded to avoid
redundancy since the primary constituent studies were included. The remaining
182 articles were retained for coding. (See Prisma Diagram).
((((acute AND lymphoblast* AND (leukem* OR leukaem*)) OR "Precursor Cell Lymphoblastic Leukemia-Lymphoma"[Mesh]))
(Infan* OR newborn* OR new-born* OR perinat* OR neonat* OR baby OR baby* OR babies OR toddler* OR minors OR minors* OR boy OR boys OR boyhood OR girl* OR kid OR kids OR child* OR children* OR schoolchild* OR (school[ti] AND child[ti]) OR adolescen* OR juvenil* OR youth* OR teen* OR underage* OR pubescen* OR pediatrics[MeSH Terms] OR pediatric* OR paediatric* OR peadiatric* OR prematur* OR preterm*) Filters: Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III; Clinical Trial, Phase IV; Controlled Clinical Trial; Randomized Controlled Trial; published in the last 10 years.