Evaluation of the Predictive Role of Standard Laboratory Tests for
Disease Severity in Patients with Deep Venous Thrombosis
Abstract
Introduction: Deep venous thrombosis (DVT) can result in fatal outcomes
if it is not timely diagnosed and sufficiently treated. Some laboratory
markers were identified in previous reports for predicting the disease
with low sensitivity or specificity. We aimed to evaluate the predictive
value of serum albumin levels and compare them with conventional
laboratory parameters. Method: Fifty patients with acute lower-extremity
DVT who has no previous history of malignancy or hematologic disorder
were included to the study. The demographical variables and standard
biomarkers of the DVT group were compared with the normal population
(n:50). Thereafter patients were divided into two groups as extensive
DVT (thrombosis involves popliteal, femoral, and iliac veins together)
and localized DVT (thrombosis involves popliteal vein and below) and
biomarkers were compared in patient groups. Results: The demographical
variables and white blood cell count (WBC) found as similar between
healthy groups and DVT groups. However, mean platelet volume (MPV),
D-Dimer, neutrophil to lymphocyte ratio (NLR), and fibrinogen to albumin
ratio (FAR) were found markedly higher in DVT patients. Moreover,
statistically incremental FAR and NLR levels were detected
(p<0.05) in patients with extensive DVT (involved iliac and
femoral veins). Conclusion: Serum NLR and FAR levels seem to be
significant predictors for the extensive thrombotic event in patients
with DVT.