Detailed Reviewer Responses


We would like to thank the reviewers for their insightful comments. The major points that have been addressed are as follows:

  1. It was not our intention to give the impression that one needs to scan human calibration phantoms at each site to properly power a multisite study with nonstandardized parameters, which is very costly. The statistical model which takes MRI bias into account has been emphasized instead. The bias that was measured and validated via calibration served to corroborate the scaling assumption of the statistical model. For other researchers planning multisite studies, the statistical model we proposed with the biases we reported should help plan and power a study.

  2. Our measurements have been compared with other harmonization efforts, specifically (Cannon 2014, Jovicich 2013)