Science AMA Series: I’m Albert Lau and I use supercomputers to simulate
molecular machines in action, such as those in the brain. My research
can help scientists understand how small molecules like
neurotransmitters locate their targets. AMA!
Abstract
Hi Reddit, my name is Albert Lau, and I’m a biophysics professor and
computational and structural biologist at Johns Hopkins University
School of Medicine. I am interested in studying how biologically
relevant molecules interact and change shape in order to carry out their
physiological functions. My lab has focused on studying proteins called
glutamate receptors that help neurons in the brain communicate with each
other and are necessary for learning and memory. We’ve been examining
the details of how neurotransmitters, specifically glutamate, manage to
bind to these receptors and what the energetic and dynamic consequences
of this binding are. My team and I recently published a paper in Neuron
that shows, in part using molecular mechanics simulations carried out on
supercomputers, that flexible protein elements on the surface of the
receptor accelerate the process of glutamate binding by grabbing
glutamate and helping to guide it into its recessed binding pocket
[http://dx.doi.org/10.1016/j.neuron.2017.11.024]. This discovery
might assist the development of new therapies for neurological disorders
and diseases associated with glutamate receptors, such as epilepsy,
depression, and Alzheimer’s disease. Over the course of my training, I
have been lucky to interact with and learn from extraordinary scientists
in the fields of structural biology, computational biophysics, and
neuroscience, and they have all influenced the research I pursue. I look
forward to answering your questions at 1pm ET.