Although IE incidence has increased due to the gradual increase of survival rate in congenital heart disease (CHD) children, the mitral and aortic valves are the most commonly involved, while tricuspid valve infection is rare, and pulmonary valve involvement is extremely rare. To improve the diagnosis in echocardiography, we described two cases of right-sided infective endocarditis (RSIE), explained the ideas of ultrasonic diagnosis, analyzed the differential diagnosis, and demonstrated the important role of echocardiography in diagnosing and treating children.