67-year-old presented with subacute left temporal lobe infarction, lumbar spine osteomyelitis, and aortic valve vegetation. Further investigations demonstrated Abiotrophia defectiva bacteremia. He was treated with penicillin and gentamicin, discharged with 4 weeks ceftriaxone. We wish to raise awareness of complications of A. defectiva endocarditis and encourage further research into treatment.