ROUGH DRAFT authorea.com/60042
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  • Tet3 and CREB

    Abstract

    Dual miRNA regulation (Schratt 2009) plays role in synaptic transmission. One of the interesting protein starting this process is Tet3 (Yu 2015) (Meadows 2015) \(\leftarrow\) Turning over DNA methylation in the mind (Lister 2015).

    Application

    Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons (Mermelstein 2001) (Tsien 1998) \(\rightarrow\) (Deisseroth 1996) (Bito 1996) (Wu 2001)

    The consolidation of new but not reactivated memory requires hippocampal C/EBPβ (Taubenfeld 2001)

    In Aplysia sensory neurons, the activity of ApCREB1 leads to the expression of several immediate-response genes, such as ubiquitin hydrolase, that stabilize STF [55], and the transcription factor CCAAT-box-enhanced binding-protein (C/EBP), whose induction has been shown to be critical for LTF [Alberini CM, Ghirardi M, Metz R, Kandel ER: C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia]

    (Kandel 2012)

    Overexpression of CREB1 can be implemented with light switchable inhibitory peptide LOV2 (Yi 2014)

    Overexpression of CREB1 can be implemented with light switchable inhibitory peptide LOV2

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