The effect of Vitamin D supplementation among antenatal women with
Gestational diabetes mellitus with Vitamin D deficiency: A Randomised
Controlled Trial
Abstract
Objective This study aimed to assess the effectiveness of high dose
vitamin D as compared to that of standard dose in women with GDM having
vitamin D deficiency. Design Randomized controlled trial Setting This
study was conducted at the Department of Obstetrics & Gynecology, All
India Institute of Medical Sciences, (AIIMS) Bhubaneswar. Population or
sample 76 women with GDM having vitamin D deficiency were included in
this study. Methods Participants were randomly recruited in intervention
and control group. Participants of the intervention group were provided
with 60,000 IU of vitamin D every two weeks (upto a maximum of ten
doses) and participants of the control group were provided with standard
dose of vitamin D (500 IU/day). All the participants were assessed for
glycemic control and perinatal outcomes. Main outcome measures Perinatal
outcomes, blood sugar levels and change in insulin requirement between
the two groups. Results Among 68 participants, mean difference of 1.06
mg/dl and 1.48 mg/dl was observed for fasting and post-prandial blood
glucose levels. Mean insulin requirement increased by 5 units in control
group during pregnancy, whereas it was reduced by 1.1 unit in
intervention group. Poor perinatal outcome was observed among 65.2% of
the participants and 34.8% amongst the participants in the intervention
group. Conclusion High dose of vitamin D supplementation is useful for
better glycemic control and preventing poor perinatal outcome among GDM
women with vitamin D deficiency. Routine Vitamin D testing and high dose
supplementation in antenatal women with proven Vitamin D deficiency
should be considered.