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Gas pressure intensifying oxygen transfer to significantly improving bio-oxidation productivity of whole-cell catalysis
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  • Xia Hua,
  • Jian Han,
  • Xin Zhou,
  • Yong XU
Xia Hua

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Jian Han
Nanjing Forestry University
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Oxygen, as a terminal electron acceptor, is an essential substrate in the aerobic bio-oxidation process, affecting bacterial vitality and bio-oxidation performance. In this study, a new and smart platform biotechnology of sealed-oxygen supply bioreactor (SOS-BR) was developed by improving gas pressure to significantly intensify oxygen transfer rate and resolving the formidable barriers of aerobic catalysis. In virtue of SOS-BR, the bio-productivity was greatly improved for three representative substrates (xylose, furfural, glycerol) bio-oxidation with the whole-cell catalysis of Gluconobacter oxydans. The determination of oxygen transfer coefficient (KLα) established an upgraded theoretical dynamic model for gas pressure intersification biosystem. Additionally, viscosity measurement and combined pressure control strategy explained the inflection point phenomenon of productivity and confirmed the intensify mechanism. The new strategy of significantly intensifying oxygen transfer provided insightful ideas for overcoming the subbon obstacle of obligate aerobic catalysis, and further promoted industrial practicability of bio-oxidation.
20 Aug 2022Submitted to AIChE Journal
20 Aug 2022Submission Checks Completed
20 Aug 2022Assigned to Editor
20 Aug 2022Reviewer(s) Assigned
11 Oct 2022Review(s) Completed, Editorial Evaluation Pending
13 Oct 2022Editorial Decision: Revise Major
19 Oct 20221st Revision Received
20 Oct 2022Submission Checks Completed
20 Oct 2022Assigned to Editor
20 Oct 2022Review(s) Completed, Editorial Evaluation Pending
22 Oct 2022Reviewer(s) Assigned
14 Nov 2022Editorial Decision: Accept
Mar 2023Published in AIChE Journal volume 69 issue 3. 10.1002/aic.18005