A case of hypertrophic obstructive cardiomyopathy complicated with paroxysmal supraventricular tachycardia is reported in this paper. The main clinical manifestations of the patient were shortness of breath after activity, palpitation that appeared gradually and transient amaurosis. There was no significant relief of symptoms after the application of β- blocker and other drugs, and color doppler echocardiography indicated that the pressure difference of left ventricular outflow tract increased gradually. The patient was treated with supraventricular tachycardia radiofrequency ablation combined with ventricular septal radiofrequency ablation under the guidance of intracardiac ultrasound.The symptoms of palpitation, shortness of breath and amaurosis disappeared, and the quality of life and exercise endurance of the patient were significantly improved when the first follow-up at 1 month was performed after the operation. The purpose of this case is to provide ideas for the end point, energy selection and prognosis criteria of ventricular septal ablation for hypertrophic obstructive cardiomyopathy by analyzing the clinical and surgical data of the patient.