Abstract

A previous study has reported cryptococcal meningoencephalitis in a previously healthy adult affected with H1N1 influenza. Here, we report cryptococcosis occurred in a previously healthy child with H3N2-influenza, which further suggests a potential association between cryptococcosis and influenza viral infection. In this case, a 5-year-old girl presented with fever and cough was admitted to our hospital with positive test for H3N2 influenza and pulmonary infiltration by chest CT scan. After antibiotic regimens, the clinical symptoms were not improved at all. Her bone marrow culture proved Cryptococcus infection. Following treatments with amphotericin B liposome and flucytosine, her body temperature returned to normal. Pulmonary infection was completely absorbed following oral fluconazole treatment for 6 mon.