Tourette syndrome research highlights 2015

Cheryl A. Richards, Ph.D. (1,2),* Kevin J. Black, M.D. (1,3-5) (ORCiD)

Departments of (1) Psychiatry, (2) Medicine, (3) Neurology, (4) Radiology, and (5) Neuroscience, Washington University School of Medicine, St. Louis, Missouri, USA

* Address correspondence to Dr. Richards at Campus Box 8134, 660 S. Euclid Ave., St. Louis, Missouri, USA or

AbstractWe present selected highlights from research that appeared during 2015 on Tourette syndrome and other tic disorders. Topics include phenomenology, comorbidities, developmental course, genetics, animal models, neuroimaging, electrophysiology, pharmacology, and treatment. We briefly summarize articles whose results we believe may lead to new treatments, additional research or modifications in current models of TS.


This article is the second in the TS Research Highlights series (Richards and Black, 2015). These articles are meant to disseminate recent scientific progress on Gilles de la Tourette Syndrome (TS). During each year, the article will be a work in progress, maintained as a web page on the Authorea online authoring platform (the working draft for 2016 appears here). After the calendar year ends, the article is finalized and submitted as the annual update for the Tics channel on F1000Research (Black, 2014).


We searched PubMed on 22 Jan 2016 using the search strategy: ("Tic Disorders"[MeSH] OR Tourette NOT Tourette[AU]) AND 2015[PDAT]. This search returned 202 citations and includes articles appearing online in 2015 but not officially published by year end (from journals that still focus on the paper user interface). We also reviewed F1000Prime recommendations and presentations of interest at selected medical conferences. Articles were chosen based on a purely subjective assessment of interest, guided by our judgment of possible future impact on the field. Some sections conclude with short tables listing additional articles.