Background: In 2001, Dr. Sardjito Hospital initiated a systematic hospital-based registry, Yogyakarta Pediatric Cancer Registry (YPCR). This study aims to present an epidemiological profile of childhood malignancies diagnosed in Dr. Sardjito General Hospital and compare it with the previous study ¹ Methods: Childhood cancer was diagnosed in children aged 0-18 years, from January 2009 to December 2018, and analyzed. Childhood malignancies were categorized based on age, sex, and disease group according to the International Classification of Childhood Cancer (ICCC-3). An estimated annual average incidence rate (AAIR) of childhood cancer was calculated. We visualized the number of patients and their regions of origin by geographic mapping. Result: There were 1,788 new cases registered in YPCR during the study period. Of these, 58% were male, with a male-to-female.4:1.0. The mean age at diagnosis was 6.3 years old, the median age was 5 years and 56% of cancers were diagnosed in the age group of 0-5 years old. The most common diagnosis category was leukemia (ICCC-3 Category I), which accounted for 60% of all childhood malignancies. The three most common diagnoses included: ALL (44%), AML (13%), and retinoblastoma (6%). Of the 1,077 patients diagnosed with leukemia, 58% were males, most often diagnosed at 0-5 years old (53%). There were 679 patients registered with solid tumors mostly diagnosed at 0-5 years old (57%). The AAIR of leukemia and solid tumors was 26.8 and 17.5 per million, respectively. Conclusion: There was an increase in the number of childhood malignancies in 2009-2018 compared to the 2000-2009 study. The number of patients referred to our hospital increased, indicating a better referral system to the pediatric cancer center. This study is expected to provide data on the hospital-based pediatric cancer registry in Indonesia and promote systematic pediatric cancer registries in other centers.