Staphylococcus hyicus (S. hyicus) is a rare, likely zoonotic infective organism. Clinically significant human infection by S. hyicus has only been recorded 3 times, where it has caused infections including cellulitis, osteomyelitis/spondylodiscitis and septicemia. (1-3). Hereafter, the case summary describes the first documented case of endocarditis due to S. hyicus.