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Resynchronization in Heart Failure: What to choose?
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  • Mohammad El Baba,
  • Moses Wananu,
  • Marwan Refaat,
  • Jayakumar Sahadevan
Mohammad El Baba
University Hospitals of Cleveland
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Moses Wananu
University Hospitals of Cleveland
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Marwan Refaat
American University of Beirut Medical Center
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Jayakumar Sahadevan
University Hospitals of Cleveland
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Abstract

Achieving Cardiac resynchronization therapy (CRT) with Biventricular pacing(BiVP) pacing for patients with moderate-to-severe heart failure (HF), left ventricular (LV) systolic dysfunction and ventricular dyssynchrony is well established and is currently the standard of care. Multiple studies have demonstrated significant improvement in quality of life, functional status, and exercise capacity in patients with New York Heart Association (NYHA) class III and IV heart failure who underwent resynchronization therapy1,2. In addition, resynchronization therapy is associated with survival benefit3. However, one third of patients do not respond to BIVP. New modalities for resynchronization have emerged namely His bundle pacing (HBP) and left ventricular septal pacing (LVSP). In this paper, we will review the benefits and limitations of BiVP and also the role of new pacing modalities such as HBP and LVSP in patients with HF with reduced left ventricular ejection fraction (LVEF) and electrical dysynchrony.

Peer review status:IN REVISION

27 May 2021Submitted to Journal of Cardiovascular Electrophysiology
01 Jun 2021Assigned to Editor
01 Jun 2021Submission Checks Completed
03 Jun 2021Reviewer(s) Assigned
10 Jul 2021Review(s) Completed, Editorial Evaluation Pending
12 Jul 2021Editorial Decision: Revise Minor