Association of dietary inflammatory potential (DIP) and endothelial
function biomarkers among female nurses of Isfahan hospitals
Abstract
Background Dietary inflammatory index (DIP) is a new dietary index
designed to evaluate individuals’ diets. In addition, adhesion molecules
are important biomarkers for assessing endothelium inflammation that
they related to atherosclerosis and cardiovascular disease. Also, there
is no study for assessing the association between adhesion molecules and
DIP until now as well as other studies that assessed the relationship
between dietary inflammatory index or DIP have controversy. Aim of the
Work The purpose of this cross-sectional study was to determine the
correlation between DII and endothelial markers such as E-selectin,
intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion
molecule-1 (sVCAM-1) among female nurses from Isfahan. In this study,
dietary inflammatory potential (DIP) was used instead of DII. Patients
and Methods This study was performed on 420 healthy nurses. The nurses
were selected by random cluster sampling method from private and public
Isfahan hospitals. A validated food frequency questionnaire (FFQ) was
applied to assess the dietary inflammatory potential. A fasting blood
sample was collected for measuring the plasma levels of the endothelial
markers and other variables. Results After adjusting different potential
confounders, no statistical association was found between DIP and
sICAM-1, E–selectin and sVCAM-1 in model I (P=0.57, 0.98 and 0.45),
model II (P=0.57, 0.98 and 0.45) and model III (P=0.67, 0.92 and 0.50)
in comparison to the crude group (P=0.35, 0.83 and 0.49, respectively).
Conclusion The results revealed that the plasma levels of endothelial
markers including E-selectin, sICAM-1, and sVCAM-1 were not
significantly associated with DIP in female nurses.