Effects of Duration of Using Intraaortic Balloon Pump on Renal Function
and Clinical Outcome
Objective:To integrate the effects of duration of using intraaortic
balloon pump (IABP) on renal function, major adverse cardiac events
(MACEs) and all-cause mortality in patients with acute myocardial
infarction (AMI) complicating pump failure. Methods:Between March 2017
and June 2018, a retrospective study enrolled 306 patients with AMI
complicating pump failure who underwent coronary artery angiography
(CAG) or percutaneous coronary intervention (PCI) was conducted.
Patients were divided into the duration ≤4 days and the duration＞4 days
in basis of median the IABP duration. We compared the renal function
parameters at the three time section of IABP implantation between two
groups. Analysis of factors of contrast-induced nephropathy (CIN),
12-month MACEs and all-cause mortality were also performed.
Results:There were 146 patients in IABP duration ≤4 days and 92 patients
in IABP duration > 4 days. Renal function was only
correlated with IABP duration instead of timing of IABP implantation. On
multivariate analysis, CIN risk increased by 81.2% (RR= 1.812, 95%CI,
1.167–3.763) for every 100mL increment of contrast agent. Hematocrit,
blood platelet, IABP use >4 days were significantly
inversely associated with CIN. Cox-regression analysis suggested that
IABP duration was not significantly correlated with the incidence of
12-month MACEs and all-cause mortality. Conclusion:Longer duration of
IABP implantation was beneficial to renal function, but was not
significantly correlated with the incidence of 12-month MACEs and
all-cause mortality in patients with AMI complicating pump failure.
Patients undergoing PCI or CABG should notice that the potential damage
of high dose of contrast agents on the renal function.