Infective endocarditis is nowadays one of the main indications for valvular surgery. When occurring in the right chambers of the heart, the tricuspid valve is the most commonly affected. Although this disease is usually present in injecting-drug abusers or patients with other predisposing risk factors, the incidence of native pulmonary valve infective endocarditis is the least frequent. This case report presents a 51-year-old patient with no relevant medical history that was admitted to our institution with sepsis. Further studies revealed a native pulmonary valve infective endocarditis complicated with infra-annular abscess and pulmonary septic embolisms. The following describes the clinical presentation of the case, echocardiograms, the surgical procedure, and the postoperative period. To date, few cases of native pulmonary valve infective endocarditis with no previous risk factors have been reported.