Complete genome and pathogenesis of a novel recombinant Senecavirus A
isolate in China
Abstract
The Senecavirus A (SVA), formerly called Seneca Valley virus (SVV) which
was first isolated in the United States (US) in 2002. In this study, a
SVA strain was isolated from a pig herd in Shandong Province in China
and designated as SVA-CH-SDGT-2017. The full-length genome, excluding
the poly (A) tail of the SVA isolates, was 7280 nucleotides long, with
the genomic organization resembling and shares high nucleotide
identities of 90.7% to 96.9% with other previously reported SVA
isolates. To investigate the pathogenicity of the SVA isolate,
experimental infections of pigs were performed. The SVA strains
successfully infected the pigs, evidenced by presence of virus shedding
and robust serum neutralizing antibody responses. Moreover, the
contact-exposed pigs showed 100-fold reduction compared to that of
inoculated group. Our findings provide useful data for studying the
pathogenesis and transmission of SVA in pigs.