Dursun Ali Kaba

and 5 more

Background: Obesity is an important, worldwide public health problem. Obesity affects all body systems, but mainly cardiovascular and respiratory systems. Aim: We aimed to investigate the change in respiratory functions due to both the decrease in body-mass index (BMI) and laparoscopic obesity surgery that is used in obesity treatment. Methods: Patients were selected who applied to Ondokuz Mayıs University General Surgery Clinics and were referred to pulmonary medicine clinics for preoperative evaluation. The mean age of patients was 35.3±9.3. 32 patients who applied for laparoscopic obesity surgery with BMI>40 kg/m2 were monitored. Pulmonary symptoms of patients were evaluated pre-operatively and post-operatively; their BMIs were calculated and pulmonary function tests, lung diffusion testing and 6 minutes walking test (6 MWT) were applied. The data obtained at the end of the study were assessed under computer setting by SPSS 15.0 program. Chi-Square, Mann Whitney U, Wilcoxon Signed Ranks, Paired T and Student T tests were used in statistical analysis of data. Results: Average age of patients was 35.3±9.3 and 28.1% of the patients (n=9) were men, 71.9% (n=23) of them were women. The fact that majority of patients who participated the study were women was related with more frequent morbid obesity in women in general; we also saw that women patients applied to the hospital for obesity surgery at a higher ratio. When data of preoperative and post-operative were compared, BMI of patients decreased by 28%; FEV₁ value, FEV₁ percentage, FVC value and FVC percentages increased by 11.9%, 14.8%, 14.8% and 17.3% respectively, and these results were accepted as statistically significant. Conclusion: Recovery in respiratory functions due to decrease in BMI was observed after laparoscopic sleeve gastrectomy in obesity. More effective routes must be followed in fighting against obesity which affect all the body systems mainly including cardiovascular and respiratory systems.

Emre Kır

and 4 more

BACKGROUND:There are studies reporting that uric acid elevation is a marker for hypoxemia and pulmonary hypertension secondary to some diseases. AIM: The aim of this study is to investigate the relationship between serum uric acid level and uric acid/creatinine ratio with COPD exacerbation, hypoxemia in exacerbation and development of cor pulmonale. METHODS: A total of 96 COPD patients who were admitted to Ondokuz Mayıs University Faculty of Medicine emergency department and Chest Diseases outpatient clinic and whose written consent was obtained, were included in our study. 43 of these patients were in the period of exacerbation (Group 1) and 53 were in the stable period (Group 2). Complete blood count, blood biochemistry (including serum uric acid level) and arterial blood gas analysis were performed in our patients. In addition, spirometry and echocardiography findings were examined. RESULTS: Serum uric acid level of Group 1 was 6.97 ± 1.34 and Group 2 was 4.30 ± 1.01 (p <0.05). Uric acid/creatinine ratios; in group 1; 8.00 ± 2.06, in group 2; It was 5.52 ± 1.57 (p <0.05). In patients with hypoxemia, serum uric acid level and uric acid / creatinine ratio were significantly higher than non-hypoxemic (p <0.05). Serum uric acid level and serum uric acid/creatinine ratio of Group 1 were significantly higher than Group 2 (p <0.001). Serum uric acid level and serum uric acid / creatinine ratio of patients who developed cor-pulmonale were significantly higher than patients without cor-pulmonale (p <0.05). CONCLUSION: Serum uric acid level and uric acid/creatinine ratio were found to be higher in patients with exacerbation of COPD and those developing cor pulmonale. Consequently, it suggests that serum uric acid level and serum uric acid/creatinine ratio may be a stimulating laboratory test for the severity of COPD and the development of COPD based cor pulmonale.