The Association between Serum Estradiol and Progesterone on the Same Day
of FET and the Pregnancy Outcome, a cross-sectional study
Abstract
Research question: Precise timed synchronization between endometrium and
the embryo is essential for high implantation and pregnancy rate, it is
worthy to mention that endometrial thickness is not the only factor, E2
and P levels are also regularly monitored for endometrial receptivity.
So, we decided to go for this study, to investigate the impact of serum
E2 and P levels on the same day of embryo transfer on pregnancy outcomes
for FET cycles. Design: This was a retrospective cross sectional study
for 402 FET cycles which conducted between April 2018 and May 2019. All
participants started endometrial preparation for FET with 6 mg/day oral
estradiol for 13 days. When endometrium reached 8 mm or greater,
patients were initiated on both micronized vaginal and oral P treatment.
On FET day, serum level of E2 and P were assessed. Then, transfer of PGT
euploid embryos was performed. 12 days later pregnancy test was
assessed, and then 4 weeks after FET date ultrasound was scheduled to
check the viability and the clinical pregnancy. Results: The mean E2
value was 931.41 ± 438.65 pg/ml, while mean P value was 8.47 ± 9.4
ng/ml. 240 out of 402 cases got pregnant (59.7%) while the clinical
pregnancy rate was 53.9% with no correlation between serum (E2, P &
E/P ratio) and the outcome. Conclusion: Our results revealed that the
association between E2 and P on FET day and the pregnancy outcome is
still not proven and those markers can’t serve as predictors for the
outcome.