loading page

Genetic architecture and heritability of early-life telomere length in a wild passerine
  • +5
  • Michael Pepke,
  • Thomas Kvalnes,
  • Sarah Lundregan,
  • Winnie Boner,
  • Pat Monaghan,
  • Bernt-Erik Sæther,
  • Henrik Jensen,
  • Thor Harald Ringsby
Michael Pepke
Norges teknisk-naturvitenskapelige universitet
Author Profile
Thomas Kvalnes
Norwegian University of Science and Technology
Author Profile
Sarah Lundregan
Norges Teknisk Naturvitenskapelige Universitet Institutt for biologi
Author Profile
Winnie Boner
Glasgow University
Author Profile
Pat Monaghan
Glasgow University
Author Profile
Bernt-Erik Sæther
Norwegian University of Science and Technology
Author Profile
Henrik Jensen
Norwegian University of Science and Technology
Author Profile
Thor Harald Ringsby
Norwegian University of Science and Technology
Author Profile

Abstract

Early-life telomere length (TL) is associated with fitness in a range of organisms. Little is known about the genetic basis of variation in TL in wild animal populations, but to understand the evolutionary and ecological significance of TL it is important to quantify the relative importance of genetic and environmental variation in TL. In this study, we measured TL in 2746 house sparrow nestlings sampled across 20 years and used an animal model to show that there is a small heritable component of early-life TL (h2=0.04), but with a strong component of maternal inheritance. Variation in TL among individuals was mainly driven by environmental (year) variance, but also brood and parental effects. We did not find evidence for a negative genetic correlation underlying the observed negative phenotypic correlation between TL and structural body size. Thus, TL may evolve independently of body size and the negative phenotypic correlation is likely to be caused by non-genetic environmental effects. We further used genome‐wide association analysis to identify genomic regions associated with TL variation. We identified several putative genes underlying TL variation; these have been inferred to be involved in oxidative stress, cellular growth, skeletal development, cell differentiation and tumorigenesis in other species. Together, our results show that TL is a lowly heritable, polygenic trait which is strongly affected by environmental conditions in a free-living bird.

Peer review status:IN REVISION

14 Apr 2021Submitted to Molecular Ecology
15 Apr 2021Assigned to Editor
15 Apr 2021Submission Checks Completed
28 Apr 2021Reviewer(s) Assigned
25 Jun 2021Review(s) Completed, Editorial Evaluation Pending
12 Jul 2021Editorial Decision: Revise Minor