TBXAS1 Gene Polymorphism is Associated with the Risk of Ischemic Stroke
of Metabolic Syndrome in a Chinese Han Population
Abstract
Metabolic syndrome (MS) is caused by genetic and environmental factors,
thromboxane A synthase 1 (TBXAS1) gene polymorphism is associated with
metabolic disease. This study would explore the relationship between
TBXAS1 gene polymorphism and MS. A total of 3072 eligible subjects were
obtained, of which 1079 cases were normal controls, 1993 cases were MS
patients. subjects were followed up for 5 years and the endpoint events
were recorded. The gene polymorphism of TBXAS1 was detected by using
Sequenom MassARRAY methods. The results showed that significant
differences were observed in ischemic stroke and the genotypes of
NC_000007.14:g.139985896C>T (all P < 0.05). The
incidence of ischemic stroke was significantly higher in T allele
carriers than in C allele carriers (all P < 0.05). C allele
was the protective factor of the onset of ischemic stroke. The
interaction effects showed there were negative interactions between C
allele and waist circumference (WC), systolic blood pressure (SBP),
diastolic blood pressure (DBP), TG, HDL-C and FPG; These findings
suggest that NC_000007.14:g.139985896C>T was related to
the incidence of ischemic stroke in the whole and MS population,
individuals who carry the C allele have a reduced risk of stroke.