Liver disorders and failure of liver is the major concern of health care providers and a point of debate since last decade. Both acute and chronic liver failure leads to death and there are a number of factors that cause liver failure portal vein hypertension is a one of the most common cause of liver failure. Portal vein is the major vessel supplying blood to the liver and it has blood pressure of approximately is 5 to 10 mmHg. And an increase in pressure causes rupturing of the parenchyma of liver which further leads to damage hepatocytes and cause their death which is the major reason behind liver failure. Diagnosis is done by various invasive or non-invasive techniques and as that to check the level and the disease stage. Few treatment options are present either to remove the damaged part or to transplant liver with the donor or cloned liver. Introduction:
There are number of innovations have been made in the field of medicine to give the ill patient the best of the treatment. As such the use of nanoparticles has also become an increasing demand because of their remarkable actions on the edge of targeted drug therapy. There are number of disorders that must be treated by the way as a specific treatment for the diseases like cancer in which the main purpose of the formation of these particles is to protect the healthy cells from the harmful effects of the drugs. And this could be only possible by making the drugs as specific in their action so these can only target the cells of interest as the abnormal one. Nano medicines are small particles which when given to the patient cause san improvement in the abnormality by better absorption and better distribution to the cells like abnormal one. So it is need of hour to make such drugs which have remarkable effects on the diseased part of body.
The entire world is dealing with this pandemic of COVID-19 since December 2019. And several variants of this SARS-COV2 virus have occurred and they have more impact on the increase in the mortality rate and it has now increased to more than 5 percent up till now which is quite an alarming state. But despite this, every day increasing mortality rate the vaccine which is now available for use is not considered to be effective by the general population due to their self-created myths and this leads them to be reluctant to the vaccine. And that's why the vaccination process is still far slow as we know that the number of cases is getting increased day by day the immunization by the vaccine is much important to cope up with this challenging pandemic. There is a need to avoid the psychological considerations for the vaccination because vaccine provision is important to provide the maximum number of individuals with the vaccine so the more complex states of this variant form of viral infection could be deal with in a more sophisticated manner.
The world has been under terror of another morbid viral pandemic which is a virus belongs to the corona virus family as SARS-COV2 (Severe acute respiratory syndrome-corona virus) related to previously existing SARS-COV (Severe acute respiratory syndrome) and MERS-COV (Middle East respiratory syndrome). It is considered to be zoonotic in origin as it is transmitted from animals to human. It presents crown like morphology with spike like protein which adheres to the surfaces of the body mainly in respiratory system. Mild symptoms like fever, dry cough, and body pain, loss of smell and taste, headache, shortness of breath appear on exposure to virus leading to major symptoms damaged lungs and drop in oxygen saturation. Pharmacological drug trials and various nutritional therapies are being used to prevent the symptoms of the infection. Researchers are developing proper vaccination to cure the infection.