Recent studies reported that the new coronavirus disease (COVID-19) invades the central or peripheral nervous system by various mechanisms including angiotensin converting enzyme-2 receptors, blood-brain barrier injury, and immune injury. The possibility that COVID-19 can occur due to the mechanism of thromboembolic stroke, as a result central nervous system, was confirmed by brain images and laboratory test. What we need to note is that COVID-19 can also appear as a focal neurological defect. In addition, if the COVID-19 patient has a high D-dimer and an inflammatory maker, clinicians must be aware of multiple thromboembolic strokes as well as the occurrence of ischemic stroke caused by large vessel stroke.