Introduction Chorioangioma is a benign vascular tumor of the placenta that occurs in approximately 1% of pregnancies1. The majority of cases are small and asymptomatic, with symptoms appearing in only 0.01%–0.03% of instances2. Giant chorioangiomas, defined as tumors larger than 4 cm, are remarkably rare, with a prevalence ranging from 1:9,000 to 1:50,000 3. While many chorioangiomas are detected during postnatal examination of placental histology, large chorioangiomas are associated with significant maternal and fetal complications. These include preterm labor, intrauterine growth restriction (IUGR), pre-eclampsia, polyhydramnios as well as hydrops fetalis, disseminated intravascular coagulation (DIC), and mortality 4–6.Despite significant advancements in therapeutic approaches, perinatal mortality rates remain high, estimated to be more than 30%7. Therefore, it is essential to highlight the importance of timely identification, comprehensive prenatal monitoring, and appropriate interventions to prevent fetal morbidity and mortality8. In this report, we present a case involving multiple giant chorioangiomas in a 23-year-old woman, which were associated with fetal complications and ultimately resulted in the neonate’s death due to hydrops fetalis. This case emphasizes the complexity of this condition and underscores the necessity for a multidisciplinary approach in evaluating and counseling patients with intricate fetal anomalies. This study has been reported in line with the CARE criteria9.

Although most manifestations of coronavirus infection in children are mainly related to the respiratory and gastrointestinal organs, involvement of other organs has also been seen with less prevalence. Because of the expression of virus receptors in male genitalia, this system is regarded as a potential target for this virus.

Medullary thyroid carcinoma (MTC) typically manifests as a solitary thyroid nodule, and a miliary pattern on conventional chest imaging is not commonly observed. Here, we report a 58-year-old woman with constitutional symptoms, and innumerable small nodules on chest imaging, mimicking miliary tuberculosis. Pathologic findings confirmed a diagnosis of metastatic MTC.

Key points 1- We report otitis media in eight patients with coronavirus disease-2019 (COVID-19) and no background history of otologic problems. 2- Otitis media was the first manifestation of COVID-19 in the majority of patients in this case series. 3- Effusion in the middle ear was present in six patients, three patients had typical signs of acute otitis media, with one patient having tympanic membrane perforation. 4- Hearing loss was present in majority of patients, with conductive and mild sensory-neural loss at high frequency as the underlying mechanisms. 5- Our findings suggest that otitis media should be considered a possible manifestation of COVID-19 during the current pandemic.